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KMID : 0616619990050020211
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Journal of Soonchunhyang Medical College
1999 Volume.5 No. 2 p.211 ~ p.220
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Expression pf PCNA, c-erbB-2, and p53 in breast carcinoma
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Abstract
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Breast carcinoma is a common malignant tumor in korea. Various oncogenes have been found in malignant tumor cells. There were many reports for correlation betwee PCNA, c-erbB-2, and p53, and prognosis of breast carcinoma, but is controversial. We performed immunohistochemical stain for PCNA, c-erbB-2, and p53 for 27 cases of benign tumor and 49 cases of carcinoma of the breast and evaluated expression rate of each antigens, and we compared their correlation with prognosis of patients in breast carcinoma.
The results were as follow;
1) PCNA LI of benign tumor and carcinoma of breast were 74.04±17.85 and 71.86±21.57. c-erbB-2 expression rates were 85.19% and 79.59%, and p53 were 0% and 51.02%.
2) PCNA LI showed no difference according to types of benign tumor and to types, histologic grade, and lymph node metastatic status of carcinoma.
3) c-erbB-2 showed higher expression rate in grade Ⅱ(87.5%) and grade Ⅲ(88.89%) than grade Ⅰ(62.50%) in breast carcinoma but it was not significant difference.
4) p53 showed significantly higher expression rate in left side and non-metastatic cases compared to right side and metastatic cases(each p＜0.05), and it showed increasing expression rate according to highening of grade without significant differnece(p=0.069).
5) The expression of p53 in breast carcinoma showed significant correlation with proliferative activity of tumor cells(P＜0.05).
Above results showed that there was correlation the expression of p53 and poor prognosis of patients and proliferative activity of tumor cells in breast carcinoma. c-erbB-2 showed indistinctive correlation with prognosis and no correlation with proliferative activity of tumor cells. PCNA showed no relation to prognosis
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